LUOYANG FUDAU BIOTECH CO.LTD.--Cell Culture Consumables

  Cell culture consumables are necessary items for culturing cells, and play an important role in creating a good growth environment for cells and ensuring their normal reproduction. Cells are sensitive to the environment, especially the requirements for consumables are relatively high, and one of the most important points is the surface TC treatment. Cell Factory Systems TC treatment is a treatment method, and the cell culture consumables treated with TC can promote cell adherent growth and morphological extension. At present, adherent cell culture is still the mainstream culture method in the market, and most animal cells need to be attached to a solid phase interface to grow. Cells can only attach to a hydrophilic solid phase interface. The earliest cell culture vessels were made of glass. Because the surface of the glass is hydrophilic, the surface can be suitable for cell growth without special treatment. However, most of the cell culture consumables on the market are mainly polym

  Adherent cells are relatively common cell types. The growth of this type of cells must have a support surface that can be attached, and the cells can grow and reproduce on the surface by relying on the attachment factors secreted by themselves or provided in the medium. Commonly used cell culture consumables for culturing adherent cells include   cell factory systems , cell culture roller bottles, and cell culture flasks. Cell factory systems: Cell culture consumables commonly used in large-scale culture, consisting of one or more layers of structure, common ones are 1 layer, 2 layers, 5 layers, 10 layers, 40 layers, etc., and the layers are connected by ultrasonic welding process , the strength of its junction is close to that of a whole piece of continuous material, which can achieve good sealing. Cell Factory Systems Cell culture roller bottles: a high-quality consumable that can meet the requirements for large-scale production of cells and tissues in both experiments and industri

  August 24, 2023, The U.S. Food and Drug Administration today approved Tyruko (natalizumab-sztn), the first biosimilar to Tysabri (natalizumab) injection for the treatment of adults with relapsing forms of multiple sclerosis (MS). Tyruko, like Tysabri, is also indicated for inducing and maintaining clinical response and remission in adult patients with moderately to severely active Crohn’s Disease (CD) with evidence of inflammation who have had an inadequate response to, or are unable to tolerate, conventional CD therapies and inhibitors of TNF-α (tumor necrosis factor, a substance in your body that causes inflammation). “Biosimilar medications offer additional effective treatment options that have the potential to increase access for people living with relapsing forms of multiple sclerosis,” said Paul R. Lee, M.D., Ph.D., director of the Division of Neurology 2 in the FDA’s Center for Drug Evaluation and Research. “Today’s approval could have a meaningful impact for patients managing

  Cell culture consumables are necessary items for culturing cells, and play an important role in creating a good growth environment for cells and ensuring their normal reproduction. Cells are sensitive to the environment, especially the requirements for consumables are relatively high, and one of the most important points is the surface TC treatment. Cell Factory Systems TC treatment is a treatment method, and the cell culture consumables treated with TC can promote cell adherent growth and morphological extension. At present, adherent cell culture is still the mainstream culture method in the market, and most animal cells need to be attached to a solid phase interface to grow. Cells can only attach to a hydrophilic solid phase interface. The earliest cell culture vessels were made of glass. Because the surface of the glass is hydrophilic, the surface can be suitable for cell growth without special treatment. However, most of the cell culture consumables on the market are mainly polym

  Most of the cells cultured in vitro belong to adherent cells. The growth of this type of cells must have a support surface that can be attached. Cells can grow and reproduce on the surface by relying on the attachment factors secreted by themselves or provided in the medium. So, what are the requirements for cell culture consumables for adherent cells? Cell Factory Systems The anchorage-dependent cells should be attached to the wall of the culture (flask) vessel during culture. Once the cells are attached to the wall, they will spread rapidly, then start mitosis, and soon enter the logarithmic growth phase. Generally, after a few days, the culture surface will be covered and a dense monolayer of cells will be formed. Cell culture consumables for adherent cells include  cell factory systems , cell culture plates, cell culture roller bottles, etc. At present, most of the cell consumables on the market are polymer materials such as PS, PC, which do not have glass materials. Due to its h

  The wide application of plastic materials has played a positive role in promoting industrial and agricultural production, facilitating people's lives, and meeting scientific research needs. With the advancement of science and technology and the continuous improvement of various processing techniques, plastic   cell culture roller bottles   have gradually replaced glass bottles and become a trend. Cell culture roller bottles are a kind of special consumables for cell culture work, and have been widely used in immunotherapy, biopharmaceuticals, stem cell therapy and other fields. The cell culture roller bottles are in the shape of a straight barrel with a narrow mouth, and the inner wall is used for the adherent culture of animal cells. With the help of the adjustment of the speed of the cell culture spinner machine, it can meet the conditions required for the culture of suspension cells or adherent cells, effectively increasing the cell culture area and promoting cell growth. The

  As a multi-layer cell culture container,   cell factory systems   are widely used in vaccine preparation, biomedicine, cell therapy and other fields. The correct operation method is the key to ensure the effect of cell culture, so we need to pay attention to the following points when culturing cells: 1. Preheating in advance: The cell factory systems are a commonly used tool for large-scale cell culture. Due to the relatively large culture area, it takes a long time to reach the set culture temperature. We can preheat the container and the required medium before the start of the experiment, which can effectively accelerate the speed of cell attachment and help improve the cell recovery rate. 2. Horizontal placement: Whether the cells are evenly distributed is also one of the factors that affect cell growth, so we must pay attention to horizontal placement when placing the culture container to avoid uneven cell distribution due to uneven surface. Cell Factory Systems 3. Slow operation

  Today, with the rapid development of science and technology, cell culture technology is widely used in various scientific research fields such as cytology, immunology, and experimental medicine to help the research and development of various new vaccines and anti-tumor drugs. Cell culture requires a specific environment. Therefore, cell culture consumables, which are necessary containers, generally have the following characteristics: 1. High transparency: Common raw materials for cell consumables include PC, PS (polystyrene), PETG, etc. These materials have a high degree of transparency. Make corresponding adjustments. Cell Factory Systems 2. No DNase/RNase: Cell growth has relatively high requirements for the environment, and it needs to be carried out under suitable conditions such as temperature, osmotic pressure, and pH. Among them, the absence of DNase and RNase means that the cell consumables have undergone special sterilization. Treatment eliminates various factors that hinder

  July 20, 2023 --(BUSINESS WIRE)--Daiichi Sankyo (TSE: 4568) today announced that Vanflyta (quizartinib) has been approved by the U.S. Food and Drug Administration (FDA) in combination with standard cytarabine and anthracycline induction and cytarabine consolidation, and as maintenance monotherapy following consolidation chemotherapy, for the treatment of adult patients with newly diagnosed acute myeloid leukemia (AML) that is FLT3-ITD positive as detected by an FDA-approved test. Vanflyta is not indicated as maintenance monotherapy following allogeneic hematopoietic stem cell transplantation (HSCT); improvement in overall survival with Vanflyta in this setting has not been demonstrated. AML is one of the most common forms of leukemia in adults and an estimated 20,380 new cases will be diagnosed in the U.S. in 2023.1 Up to 37% of newly diagnosed patients with AML have a FLT3 gene mutation and approximately 80% of these are FLT3-ITD mutations, which drive cancer growth and contribute t

  Aug. 5, 2023 /PRNewswire/ -- Astellas Pharma Inc. (TSE: 4503, President and CEO: Naoki Okamura, "Astellas"), today announced the U.S. Food and Drug Administration (FDA) approved Izervay™ (avacincaptad pegol intravitreal solution) for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) on August 4, 2023. Izervay, a new complement C5 inhibitor, is the only approved GA treatment with a statistically significant reduction (p<0.01) in the rate of GA progression at the 12-month primary endpoint across two Phase 3 clinical trials. Pravin U. Dugel, MD, President, Iveric Bio, An Astellas Company "We are thrilled to receive FDA approval of Izervay and to offer a new therapy to physicians and appropriate patients in the U.S. Time matters, vision matters, and safety matters in this devastating progressive disease. We would like to thank everyone involved in reaching this milestone and helping us deliver on our commitment to pioneer trans

  PETG media bottles   are a special packaging for storing various media, reagents, serum and other solutions, and it is also a product that scientific researchers have more contact with. The wide range of applications is mainly due to the superior properties of its materials. PETG is a transparent plastic that belongs to the non-crystalline copolyester. Serum needs to be stored in a low temperature environment. The use range of this material is -80°C to 60°C, which makes PETG media bottles fully meet the storage needs of serum. In addition, it has the following features: 1. High transparency, the light transmittance reaches 90%, which can reach the transparency of plexiglass; 2. It has stronger rigidity and hardness, excellent scratch resistance, impact resistance and toughness, which is close to or even exceeds that of polycarbonate (PC), and is suitable for injection molding, extrusion molding and extrusion blowing processing; 3. In terms of chemical resistance, oil resistance, weat

  In the field of biopharmaceuticals, cell culture consumables are essential tools. Among them, the   cell factory systems   has become a commonly used consumable in biopharmaceuticals due to its small footprint, reduced pollution. It is mainly used in small test, pilot test, mass production and other links. Small test, pilot test, and scale-up are three very important links in biopharmaceuticals. The small test is scaled up according to the laboratory effect. The pilot test is the test before the product is officially put into production, and it is a small-scale test of the product before mass production. Master the basic parameters of the process in the small test stage, write the pilot test plan on this basis, and carry out the pilot scale test. After the pilot test is over, the existing process of the small test will be improved and improved according to the phenomenon and results of the process amplification. In addition, the operating procedures for product production are formed.

  Cell culture roller bottles , as the name suggests, are a type of consumables used to culture cells. With the help of the cell culture spinner bottle system, it is widely used in the fields of cell biology, virology, microbiology and pharmaceutical industry. The in vitro culture of cells and tissues has become an essential content in the field of life sciences. There are a wide variety of cultured cells, from viruses to bacteria to fungi, from human cells to animal cells and plant cells. Some cells and tissues can grow in suspension, but a considerable number of mammalian cells require surface attachment, so the requirements for cell culture consumables are relatively high. Cell Culture Roller Bottles The cell culture roller bottles are suitable for the cultivation of a variety of adherent cells and suspension cells, such as Vero cells, HEK 293 cells, CAR-T cells, MRC5, CEF cells, porcine alveolar macrophages, myeloma cells, DF- 1 cells, ST cells, PK15 cells, Marc145 cells and other

  Cell culture roller bottles   are a common cell culture consumable in the field of life sciences, it is mainly used for culturing and expanding biological cells in vitro. It can provide a large growth surface for cells, and prevent certain components formed in the culture medium from possibly affecting cell growth through slight rotation. In the production of veterinary vaccines, this consumable is mainly used for the cultivation of cells or viruses. The following are some common examples of cell culture spinner bottles used in veterinary vaccine production: Swine influenza vaccine: The production of swine influenza vaccine will use cell culture roller bottles to amplify the virus, and extract surface glycoproteins (H and N antigens) from it for vaccine preparation. Cell Culture Roller Bottles PRRS Vaccine: This disease was once known as "Mystery Pig Disease", "New Pig Disease", "Porcine Epidemic Abortion and Respiratory Syndrome", "Porcine Reproduc

  The   cell culture roller bottles   are a high-quality consumable that can meet the requirements for large-scale production of cells and tissues in both experiments and industrial production. It is widely used in the cultivation of animal and plant cells, bacteria, and viruses. Contamination is often encountered during cell culture. The common types of pollution are as follows: 1. Bacterial contamination Bacteria look like black fine sand under an ordinary inverted microscope, and may have different shapes according to the different infected bacteria. The culture medium generally turns turbid and yellow, which has a significant impact on cell growth, and most of the cells die within 24 hours. 2. Mold pollution The culture solution in the cell culture roller bottles is clear, and there is no impurity under the inverted microscope. After 2-3 days in a 37-degree incubator, it is still clear, but there are flocculent impurities. Cells can still grow when obvious hyphae are seen, but afte

  Cell cell culture roller bottles   are generally used in cell culture at the same time as spinner bottles, which can change cell culture from static to dynamic. It is a simplified bioreactor and is suitable for the cultivation of suspension cells and adherent cells. This cell culture method Known as cell culture roller bottles culture technology. Cell culture roller bottles culture is a cell transition stage before the maturity of large-scale culture technology. It can be used as a way for bioreactor inoculation of cell culture medium preparation . Compared with traditional static monolayer culture, cell culture roller bottles culture technology has three advantages: 1. Provide a larger growth surface for cells; 2. Slight rotation can prevent some components formed in the culture medium from possibly affecting cell growth; Cell Culture Roller Bottles 3. Cells are only covered with a thin layer of culture medium most of the time, which is conducive to gas exchange; 4. Simple structure

  In recent years, the biomedical industry has ushered in unprecedented development opportunities. In this wave of rapid change, a revolutionary technology has attracted widespread attention, and that is the  cell factory systems . As a representative of a new generation of biopharmaceutical production process, it opens a new situation for large-scale production of high-quality biopharmaceuticals. Traditional biopharmaceutical production processes often rely on tedious cell culture techniques that are time- and resource-intensive. However, the emergence of cell factory systems has completely changed this phenomenon. It uses engineered cell lines and advanced automation technology, which greatly simplifies and speeds up the production process of drugs. By optimizing cell culture conditions, controlling culture parameters and implementing fixed-point detection, a large number of consistent biopharmaceuticals can be efficiently produced, providing strong support for the pharmaceutical ind

  In addition to paying attention to the changes in temperature, osmotic pressure, pH value and other conditions when culturing cells, it is also very important to grasp the growth status of cells. The   cell factory systems   are a multi-layer culture container, how should we observe the state of the cells? 1. Optical microscope observation: The morphology, structure and certain organelles of cells in the cell factory systems can be observed using an optical microscope. By adjusting the magnification and focal length of the microscope, images of different magnifications can be obtained to observe the details of cells. 2. Staining observation: By using cell staining technology, specific structures or components of cells can be displayed in color for easy observation. Commonly used staining methods include fluorescent staining and nucleic acid staining. Fluorescent staining can be used to observe the distribution and localization of specific markers through fluorescence microscopy, whil

  Cell culture roller bottles   are a kind of cell consumables for cell culture. Through the supporting application of cell spinner bottle culture machines, they are suitable for large-scale cell culture. In the quality requirements of cell consumables, biocompatibility testing is essential, and it is the key to ensure that cells can be successfully cultured in this environment. Biocompatibility refers to the biological, physical and chemical reactions caused by biological materials in specific parts of the body, that is, whether certain materials or drugs are "compatible" with the body or implanted in the body, and will not cause harm to the human body. Cell Culture Roller Bottles The biocompatibility of cell culture roller bottles requires that biomaterials have very low toxicity, and at the same time require that biomaterials can properly stimulate the corresponding functions of the body in specific applications. The evaluation of biocompatibility mainly refers to the requ

  Cell culture roller bottles   are one of the common consumables for cell culture, which is suitable for the cultivation of animal and plant cells, bacteria and viruses. With the vigorous development of the field of biomedicine, some pharmaceutical companies have continuously increased their investment in new drug research and development, and cell consumables have gained popularity. With rapid growth, its production process is also constantly updated and iterated. Due to the particularity of the application industry, cell culture roller bottles have high quality requirements, and there are strict standards from the material of the bottle to the production process. Cell culture roller bottles use medical polymer materials as raw materials. Generally, one-step injection stretch blow molding process is used, also called one-step injection stretch blow production process. The principle is to use the heat retained during preform molding to stretch to blow molding. Compared with the produc