Which aspects of the cell factory systems are mainly used in biopharmaceuticals

 In the field of biopharmaceuticals, cell culture consumables are essential tools. Among them, the cell factory systems has become a commonly used consumable in biopharmaceuticals due to its small footprint, reduced pollution. It is mainly used in small test, pilot test, mass production and other links.

Small test, pilot test, and scale-up are three very important links in biopharmaceuticals. The small test is scaled up according to the laboratory effect. The pilot test is the test before the product is officially put into production, and it is a small-scale test of the product before mass production. Master the basic parameters of the process in the small test stage, write the pilot test plan on this basis, and carry out the pilot scale test. After the pilot test is over, the existing process of the small test will be improved and improved according to the phenomenon and results of the process amplification. In addition, the operating procedures for product production are formed. After the procedures have been verified by more than three consecutive batches of processes, they can be used as the process basis for large-scale production. The processes of each stage are inherited in one continuous line.

Cell Factory SystemsCell Factory Systems

The specifications of the cell factory systems used in different stages will be different. In the small-scale test stage, 1-layer and 2-layer small specifications are mainly used, while the pilot test will use 5-layer and 10-layer specifications, and the mass production stage is mainly based on 40-layer cell factory systems.

In general, cell factory systems of different specifications are used in different stages of biopharmaceuticals. It is worth mentioning that in the later stage of large-scale production, it can be matched with the corresponding pipeline system to realize the airtight transfer of liquid and reduce the risk of external source pollution during operation.


评论

发表评论

此博客中的热门博文

Material features of PETG media bottles

图片
  PETG media bottles   are a special packaging for storing various media, reagents, serum and other solutions, and it is also a product that scientific researchers have more contact with. The wide range of applications is mainly due to the superior properties of its materials. PETG is a transparent plastic that belongs to the non-crystalline copolyester. Serum needs to be stored in a low temperature environment. The use range of this material is -80°C to 60°C, which makes PETG media bottles fully meet the storage needs of serum. In addition, it has the following features: 1. High transparency, the light transmittance reaches 90%, which can reach the transparency of plexiglass; 2. It has stronger rigidity and hardness, excellent scratch resistance, impact resistance and toughness, which is close to or even exceeds that of polycarbonate (PC), and is suitable for injection molding, extrusion molding and extrusion blowing processing; 3. In terms of chemical resistance, oil resistance, weat
阅读全文

What are the common specifications of serum bottles

图片
  In biological laboratories, we often have to store various solutions and reagents. Thanks to the advantages of good performance, transparency, and temperature resistance, serum bottles have become "frequent visitors" in the laboratory. As a commonly used storage container, what are its common specifications?                      FuDau 60ml-Square-PETG-PET-Media-Bottles Common materials for serum bottles include PETG and PET, both of which have very good temperature resistance and transparency. In comparison, bottles made of PETG have more advantages in terms of barrier properties. If you want to pursue a better storage state of the solution, it is recommended to use a bottle made of PETG. There is a molded scale on the body of the bottle, we can clearly observe the capacity and state of the solution. The common specifications of this kind of container include 5ml/10ml/30ml/60ml/125ml/250ml/500ml/1000ml, etc., which are mostly used to store serum, culture medium, buffer, dis
阅读全文

Cell factory requirements for production raw materials

图片
Cell factories   are mainly used for large-scale cell culture. Cells have high requirements on the environment, such as temperature, humidity, osmotic pressure, pH value, etc. Therefore, this kind of   cell   consumables also has high requirements on raw materials. The first is transparency. In the process of cell culture, it is necessary to grasp the growth state of the cells at any time, and make corresponding adjustments according to the cell proliferation. Therefore, the raw materials of the cell factory must meet the requirements of transparency, so that it is convenient for researchers to observe the growth of cells. The second is the compatibility of materials. The raw materials of this consumable generally meet the requirements of USP Class VI medical polymer materials. Medical polymer materials refer to polymer materials used to manufacture human internal organs, external organs, pharmaceutical dosage forms and medical devices, and their sources include natural biopolymer mate
阅读全文